邻氯西林钠一水合物 Cloxacillin Sodium CAS#:7081-44-9

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邻氯西林钠一水合物

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CAS号：7081-44-9 | 英文名称：Cloxacillin Sodium

分子式

分子量

EINECS号

MDL

Smiles

InChIKey

乙二醇化学百科

基本信息

物化性质

安全信息

生产及用途

Cloxacillin Sodium是Cloxacillin的钠盐形式，是一种耐青霉素酶，耐酸，半合成的青霉素。

Cloxacillin is an antibiotic useful for the study of a number of bacterial infections.

Cell Viability Assay

Cell Line:	Strains M12 and M60.
Concentration:	0.5 μg/mL.
Incubation Time:	4-24 h.
Result:	Significantly reduced the bacterial numbers.

Cloxacillin sodium (50 mg/kg, Subcutaneously) results a significant antibiotic efficacy against S. aureus .

Animal Model:	Mice.
Dosage:	10 mg/kg ( Pharmacological Analysis ).
Administration:	Given subcutaneously.
Result:	Reached a maximal concentration in plasma of 8.4 μg/mL at 10 min and had a half-life of approximately 15 min.

Animal Model:	Mice injected with approximately 2 × 10 ⁶ CFU of bacteria in 0.1 mL saline were aseptically injected into the right thigh muscle.
Dosage:	0–500 mg/kg.
Administration:	Subcutaneously in the nuchal region at 1 h after infection.
Result:	Resulted in a significant decrease in the number of viable S. aureus measured 18 h thereafter.