ALPHA-玉米赤霉烯醇 ALPHA-ZEARALENOL CAS#:36455-72-8

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ALPHA-玉米赤霉烯醇

产品纠错

CAS号：36455-72-8 | 英文名称：ALPHA-ZEARALENOL

分子式 C₁₈H₂₄O₅

分子量 320

EINECS号 828-728-1

MDL MFCD16657008

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	ALPHA-玉米赤霉烯醇
英文名称	ALPHA-ZEARALENOL
CAS号	36455-72-8
分子式	C18H24O5
分子量	320.38
EINECS号	828-728-1

物化性质

熔点	158-161°C
沸点	599.0±50.0 °C(Predicted)
密度	1.174±0.06 g/cm3(Predicted)
闪点	2℃
溶解度	乙醇中≤20mg/ml；DMSO 中≤30mg/ml；二甲基甲酰胺中≤30mg/ml
形态	结晶固体
酸度系数(pKa)	7.61±0.60(Predicted)
颜色	白色至米白色
稳定性	吸湿性

安全信息

危险品标志	Xn,T,F
危险类别码	20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45
安全说明	36/37-61-16-45-53
危险品运输编号	UN 1648 3 / PGII
WGK Germany	3
F	8
海关编码	29322090

生产及用途

生物活性

α-Zearalenol 是一种对雌激素受体 (ER) 具有高亲和力的霉菌毒素, α-Zearalenol 是 zearalenone (ZEN) 的衍生物，由于其异种雌激素效应可引起动物的生殖障碍。

体外研究

α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC ₅₀ of 12.5 μM. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations.

Cell Proliferation Assay

Cell Line:	MFC-7 cells
Concentration:	6.25 µM-25 µM
Incubation Time:	24 hours
Result:	Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells.

Cell Viability Assay

Cell Line:	Breast cancer cell lines: MCF-7 and MDA-MB231
Concentration:	0.001 μM, 0.1 μM and 10 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Modified the cell growth in two breast cancer cell lines.

Cell Cycle Analysis

Cell Line:	MCF7 cells, MDA-MB231 cells
Concentration:	0.001 μM, 0.1 μM and 10 μM
Incubation Time:	72 hours
Result:	Observed an increase of cells in cell cycle in MCF7 cells.

RT-PCR

Cell Line:	HepG2 cells
Concentration:	1 μM, 5 μM, 10 μM
Incubation Time:	72 hours
Result:	Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.

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