红陪酚 PURPUROGALLIN CAS#:569-77-7

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氯化钾 | 乙二醇 | 碘甲烷 | 溴化亚铜 | 叔丁醇钾 | DMAP

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首页化工产品目录红陪酚

红陪酚

产品纠错

CAS号：569-77-7 | 英文名称：PURPUROGALLIN

分子式 C₁₁H₈O₅

分子量 220

EINECS号 209-324-9

MDL MFCD00004145

Smiles C12=C(O)C(O)=C(O)C=C1C=CC=C(O)C2=O

InChIKey WDGFFVCWBZVLCE-UHFFFAOYSA-N

乙二醇化学百科

基本信息

中文名称	红陪酚
英文名称	PURPUROGALLIN
CAS号	569-77-7
分子式	C11H8O5
分子量	220.18
EINECS号	209-324-9

物化性质

熔点	275 °C (dec.)(lit.)
沸点	321.11°C (rough estimate)
密度	1.3824 (rough estimate)
折射率	1.5140 (estimate)
LogP	2.050 (est)
溶解度	可溶于DMSO（少许）、甲醇（少许）
形态	固体
酸度系数(pKa)	6.75±0.20(Predicted)
颜色	深棕色低熔点
Merck	7946
稳定性	空气敏感

安全信息

危险品标志	Xi
危险类别码	36/37/38
安全说明	26-36
WGK Germany	3
RTECS号	DE8380000

生产及用途

生物活性

Purpurogallin 是从栎属植物中提取的天然酚，具有强的黄嘌呤氧化酶 (Xanthine Oxidase) 抑制活性，其 IC50 为 0.2 µM。Purpurogallin 具有抗氧化和抗炎作用。

靶点

IC50: 0.2 µM (xanthine oxidase)

体外研究

Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.
Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells.

RT-PCR

Cell Line:	BV2 murine microglial cells
Concentration:	50 or 100 µM
Incubation Time:	7 or 25 hours
Result:	Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression.

Western Blot Analysis

Cell Line:	BV2 murine microglial cells
Concentration:	100 µM
Incubation Time:	75 minutes, 90 minutes, 120 minutes
Result:	Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways.

体内研究

Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.

Animal Model:	Fifty-four male Sprague-Dawley rats (250-350 g) with subarachnoid hemorrhage (SAH)
Dosage:	100 μg/kg, 200 μg/kg, 400 μg/kg
Administration:	Intraperitoneal injection; for 48 or 72 hours
Result:	Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels.

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