石苁蓉萘醌 (LC&T) Plumbagin CAS#:481-42-5

基本信息

中文名称	兰雪醌
英文名称	PLUMBAGIN
CAS号	481-42-5
分子式	C11H8O3
分子量	188.18
EINECS号	207-569-6

物化性质

熔点	76-78 °C(lit.)
沸点	283.17°C (rough estimate)
密度	1.354
折射率	1.6310 (estimate)
LogP	2.450 (est)
溶解度	在热甲醇中有非常微弱的浑浊
形态	晶体或结晶粉末
酸度系数(pKa)	6.70±0.20(Predicted)
颜色	橙色
Merck	7538
稳定性	吸湿性

安全信息

危险品标志	T
危险类别码	25-34-36/37/38
安全说明	22-26-36/37/39-45-37/39-28A
危险品运输编号	UN 2923 8/PG 2
WGK Germany	3
RTECS号	QL8500000
Hazard Note	Toxic
海关编码	29146990
危险等级	6.1(a)
包装类别	II
毒性	LD50 i.p. in mice: ~0.015 g/kg (Debray)

生产及用途

生物活性

Plumbagin (2-Methyljuglone) 是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖活性。

体外研究

Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner.
Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells.

Apoptosis Analysis

Cell Line:	DU145, CWR22rv1, LNCaP and RWPE-1 cells
Concentration:	0, 5, 10, and 15 μM
Incubation Time:	24 hours
Result:	Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM.

体内研究

Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice.
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice.

Animal Model:	Male athymic nude mice bearing DU145 cells
Dosage:	2 mg/kg
Administration:	I.P. after 3 days post cell implantation, five days a week.
Result:	Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice.

用途

用作染料中间体，用于生产26紫、28紫、双氰等

上下游产品

上游产品共计:38个

下游产品共计:0个