CasImg
辅酶Q9
产品纠错
CAS号:303-97-9 | 英文名称:COENZYME Q9
分子式 C54H82O4
分子量 795
EINECS号 215-668-0
MDL MFCD00056635
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 辅酶Q9
英文名称 COENZYME Q9
CAS号 303-97-9
分子式 C54H82O4
分子量 795.23
EINECS号 215-668-0
物化性质
熔点 41-43°C
沸点 826.8±65.0 °C(Predicted)
密度 0.97±0.1 g/cm3(Predicted)
溶解度 可溶于氯仿(轻微)、乙酸乙酯(轻微)、甲醇(轻微、加热)
形态 固体
颜色 黄色至橙色粘性至蜡状
BRN 1900081
稳定性 感光
安全信息
安全说明 22-24/25
WGK Germany 2
RTECS号 DK4786000
F 8-10
海关编码 29146990
毒性 LD50 oral in rat: > 4gm/kg
生产及用途
Coenzyme Q9 (Ubiquinone Q9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。Coenzyme Q9 可减轻糖尿病引起的抗氧化防御机制的下降。Coenzyme Q9 改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。

Human Endogenous Metabolite

Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury.
CoQ 10 and CoQ 9 are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ 10 , whereas CoQ 9 has been found in high concentrations in corn oil.
The lack of a functional CoQ 9 protein in homozygous CoQ 9 mutant (CoQ 9 (X/X)) mice causes a severe reduction in the CoQ 7 protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ 9 (X/X) mice that consequently die between 3 and 6 months of age.

Animal Model: Male Hartley guinea pigs of about 350-400 g body weight
Dosage: 5 mg/kg of body weight
Administration: P.o.; once a day for 4 weeks
Result: Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10.
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产品供应商
CoenzymeQ9
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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