CasImg
咳平盐酸盐
产品纠错
CAS号:14984-68-0 | 英文名称:Cloperastine hydrochloride
分子式 C20H25Cl2NO
分子量 366
EINECS号 239-067-8
MDL MFCD00079012
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 盐酸氯哌斯丁
英文名称 Cloperastine hydrochloride
CAS号 14984-68-0
分子式 C20H25Cl2NO
分子量 366.32
EINECS号 239-067-8
物化性质
熔点 147.9°
溶解度 可溶于DMSO(少许)、甲醇(少许)
形态 固体
颜色 白色至类白色
Merck 14,2395
安全信息
危险品标志 Xn
危险类别码 22
安全说明 36
WGK Germany 3
RTECS号 TM6491500
海关编码 2933.39.9200
生产及用途
Cloperastine hydrochloride 抑制 hERG K+ 电流,IC50 为 27 nM,这种作用具有浓度依赖性。

27 nM (K + currents)

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.
Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width.
Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

上下游产品
上游产品共计:0个
下游产品共计:0个
相关产品
产品供应商
Cloperastine hydrochloride
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

首页 |  CAS目录 |  产品目录 |  企业会员 |  关于我们 |  法律声明 |  注册协议

Copyright © 冀ICP备2024096099号