CAS号：80288-49-9
|
英文名称：Furafylline
分子式
C12H12N4O3
分子量
260
EINECS号
200-158-5
MDL
MFCD00153799
Smiles
InChIKey
呋拉茶碱化学百科
基本信息
| 中文名称 | 呋喃茶碱 |
| 英文名称 | 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE |
| CAS号 | 80288-49-9 |
| 分子式 | C12H12N4O3 |
| 分子量 | 260.25 |
| EINECS号 | 200-158-5 |
物化性质
| 熔点 | >162°C (dec.) |
| 沸点 | 543.6±60.0 °C(Predicted) |
| 密度 | 1.443±0.06 g/cm3(Predicted) |
| 溶解度 | 乙醇：0.33 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.62±0.70(Predicted) |
| 颜色 | 白色 |
安全信息
| WGK Germany | 3 |
生产及用途
Furafylline 是一种有效且有选择性的人细胞色素 P450IA2 抑制剂，其 IC50 值为 0.07 μM。
IC50: 0.07 μM (human cytochrome P450IA2)
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC 50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.
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