盐酸双环维林 DICYCLOMINE HYDROCHLORIDE CAS#:67-92-5

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盐酸双环维林

产品纠错

CAS号：67-92-5 | 英文名称：DICYCLOMINE HYDROCHLORIDE

分子式 C₁₉H₃₆ClNO₂

分子量 346

EINECS号 200-671-1

MDL MFCD00079158

Smiles C1(CCCCC1)(C(=O)OCCN(CC)CC)C1CCCCC1.Cl

InChIKey GUBNMFJOJGDCEL-UHFFFAOYSA-N

乙二醇化学百科

基本信息

中文名称	盐酸双环维林
英文名称	DICYCLOMINE HYDROCHLORIDE
CAS号	67-92-5
分子式	C19H36ClNO2
分子量	345.95
EINECS号	200-671-1

物化性质

熔点	164-166°C
溶解度	H2O:50 mg/mL
形态	粉末
颜色	米白色

安全信息

危险品标志	Xn
危险类别码	22-36/37/38
安全说明	26-36
WGK Germany	3
RTECS号	DT7350000
海关编码	2922199695
毒性	LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82

生产及用途

生物活性

Dicyclomine hydrochloride 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine hydrochloride 对 M1 受体亚型 (Ki=5.1 nM) 和 M2 受体亚型 (Ki=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine hydrochloride是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。

靶点

Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane

体内研究

Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks.

Animal Model:	C57Bl/6 mice
Dosage:	2.0, 4.0, and 8.0 mg/kg
Administration:	Intraperitoneal injection; daily; 7 days
Result:	Produced impairments due to actions of the agent outside of the hippocampus.