CasImg
吡咯烷二硫代甲酸铵
产品纠错
CAS号:5108-96-3 | 英文名称:1-Pyrrolidinecarbodithioic acid, ammoniumsalt
分子式
分子量
EINECS号
MDL
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 吡咯烷二硫代甲酸铵盐
英文名称 Ammonium pyrrolidinedithiocarbamate
CAS号 5108-96-3
分子式 C5H9NS2.H3N
分子量 164.3
EINECS号 225-834-4
物化性质
熔点 153-155 °C(lit.)
密度 1.117 (estimate)
折射率 1.5300 (estimate)
溶解度 190g/l
形态 粉末/固体
颜色 白色至类白色
PH值 6-7 (50g/l, H2O, 20℃)
水溶解性 50 g/L (20 ºC)
敏感性 Hygroscopic
BRN 3730472
稳定性 稳定的。与强氧化剂不相容。
安全信息
危险品标志 Xi,Xn
危险类别码 36/37/38-22
安全说明 26-36-37/39
WGK Germany 3
F 3
TSCA Yes
海关编码 29339990
生产及用途
吡咯烷二硫代甲酸铵盐在包括金属螯合作用在内的生物化学应用中很有用。它被用来防止一氧化氮合酶的诱导。抑制白血病HL-60细胞的凋亡也是非常重要的。Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt)是NF-κB的有效抑制剂,抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。
TargetValue
NF-κB
()

Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.

The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.

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产品供应商
Ammonium pyrrolidinedithiocarbamate
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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