LJI308 LJI308 CAS#:1627709-94-7

基本信息

中文名称	LJI308
英文名称	LJI308
CAS号	1627709-94-7
分子式	C21H18F2N2O2
分子量	368.38
EINECS号	604-604-1

物化性质

溶解度	溶于二甲基亚砜
形态	结晶固体
颜色	浅黄至黄色

安全信息

海关编码	2934999090

生产及用途

生物活性

LJI308 是一种有效的泛 RSK 抑制剂，对 RSK1、RSK2 和 RSK3 的 IC50 分别为 6 nM、4 nM 和 13 nM。LJI308 抑制辐照、EGF 处理和表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。

体外研究

LJI308 inhibits S6K1 with an IC ₅₀ of 0.8 μM.
LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells.
LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%.

Cell Viability Assay

Cell Line:	HTRY-LT cell lines
Concentration:	1-10 μM
Incubation Time:	96 hours
Result:	Decreased cell viability by up to 90%.

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