CAS号：1508-76-5
|
英文名称：PROCYCLIDINE HYDROCHLORIDE
分子式
C19H30ClNO
分子量
324
EINECS号
216-141-8
MDL
MFCD00079236
Smiles
InChIKey
丙环定盐酸盐化学百科
基本信息
| 中文名称 | 丙环定盐酸盐 |
| 英文名称 | PROCYCLIDINE HYDROCHLORIDE |
| CAS号 | 1508-76-5 |
| 分子式 | C19H30ClNO |
| 分子量 | 323.9 |
| EINECS号 | 216-141-8 |
物化性质
| 熔点 | 159-164 °C |
| 溶解度 | 氯仿（微溶）、甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
安全信息
| 危险品标志 | Xn |
| 危险类别码 | 20/21/22 |
| 安全说明 | 36 |
| WGK Germany | 3 |
| RTECS号 | UY1926000 |
| 海关编码 | 2933997500 |
| 毒性 | mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955. |
生产及用途
Procyclidine hydrochloride 是一种有效的抗胆碱能试剂，也具有NMDA拮抗剂的特性。
NMDA Receptor
Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain.
用途
An anticholinergic drug used in the treatment parkinson鈥檚 disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.上下游产品
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