槲皮万寿菊素 3,3',4',5,6,7-HEXAHYDROXYFLAVONE CAS#:90-18-6

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槲皮万寿菊素

产品纠错

CAS号：90-18-6 | 英文名称：3,3',4',5,6,7-HEXAHYDROXYFLAVONE

分子式 C₁₅H₁₀O₈

分子量 318

EINECS号 201-973-6

MDL MFCD00017428

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	六羟黄酮/栎草亭
英文名称	3,3',4',5,6,7-HEXAHYDROXYFLAVONE
CAS号	90-18-6
分子式	C15H10O8
分子量	318.24
EINECS号	201-973-6

物化性质

熔点	>300°C
沸点	732.4±60.0 °C(Predicted)
密度	1.912±0.06 g/cm3(Predicted)
LogP	2.230 (est)
溶解度	DMSO：125 mg/mL（392.79 mM；需要超声波）
形态	结晶固体
酸度系数(pKa)	6.12±0.40(Predicted)
颜色	浅黄至黄色

安全信息

生产及用途

生物活性

Quercetagetin (6-Hydroxyquercetin) 是从 Citrus unshiu (C. unshiu) 果皮中分离的主要类黄酮。Quercetagetin 是一种中等强度和选择性的，细胞渗透性的 pim-1 激酶抑制，IC50 为 0.34 μM。具有抗炎和抗肿瘤活性。

靶点

PIM1

0.34 μM (IC ₅₀ )

PIM2

3.45 μM (IC ₅₀ )

RSK2

2.82 μM (IC ₅₀ )

PKA

21.2 μM (IC ₅₀ )

体外研究

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC ₅₀ s of 3.45, 21.2, and 2.82 µM, respectively.
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED ₅₀ is 3.8 μM.

Cell Viability Assay

Cell Line:	RWPE2 prostate cancer cells
Concentration:	0.1, 1, 10, and 100 μM
Incubation Time:	72 hours
Result:	Inhibited growth of RWPE2 prostate cancer cells with average ED ₅₀ is 3.8 μM.

体内研究

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively.

Animal Model:	SKH-1 hairless mice model
Dosage:	4 or 20 nmol
Administration:	Topical application; 28 weeks
Result:	Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.

化学性质

来源于万寿菊

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