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CAS号:77-59-8
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英文名称:TOMATIDINE
分子式
C27H45NO2
分子量
416
EINECS号
201-040-3
MDL
MFCD00075644
Smiles
InChIKey
乙二醇化学百科
基本信息
物化性质
安全信息
生产及用途
Tomatidine 通过阻断 NF-κB 和 JNK 信号发挥抗炎作用。Tomatidine 激活哺乳动物细胞或秀丽隐杆线虫中的自噬 (autophagy)。
Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.
化学性质 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于番茄根茎、叶、青果中含量高,成熟的果实低。用途 番茄红素具有抗菌,抗炎,抗组胺,强心,抗癌的作用。用途 用于含量测定/鉴定/药理实验等。
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