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芬维A胺
产品纠错
CAS号:65646-68-6 | 英文名称:Fenretinide
分子式 C26H33NO2
分子量 392
EINECS号 200-256-5
MDL MFCD00792674
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 维甲酰酚胺
英文名称 4-HYDROXYPHENYLRETINAMIDE
CAS号 65646-68-6
分子式 C26H33NO2
分子量 391.55
EINECS号 200-256-5
物化性质
熔点 162-163°C
沸点 597.6±42.0 °C(Predicted)
密度 1.081±0.06 g/cm3(Predicted)
溶解度 可溶于氯仿(少许)、甲醇(少许)
形态 橙色固体
酸度系数(pKa) 9.98±0.26(Predicted)
颜色 粘黄色
最大波长(λmax) 362nm(MeOH)(lit.)
Merck 14,3998
稳定性 对光敏感,应避光保存
安全信息
危险品标志 T
危险类别码 60-61-20/21/22-36/37/38
安全说明 53-26-36/37/39-45-52
WGK Germany 3
RTECS号 VH6420000
海关编码 2924297099
生产及用途
Fenretinide (4-HPR) 是一种合成的类维生素A衍生物,能够结合视黄酸受体 (RAR) 诱导细胞死亡。

Fenretinide (4-HPR) exerts not just acute but also long term antitumor activity in selected T-ALL cell lines. Fenretinide inhibits DES activity in CCRF-CEM leukemia cells in a dose and time dependent manner, leading to a concomitant increase of the endogenous cellular dhCer content. Fenretinide (3 μM)-induced dhCer accumulation in both CCRF-CEM and Jurkat cells. Ceramide inhibition with fenretinide protects insulin signaling. Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake. Fenretinide inhibits OVCAR-5 cell proliferation and viability at concentrations higher than 1 microM, with 70-90% growth inhibition at 10 microM. Fenretinide (1 microM) significantly inhibits OVCAR-5 invasion after 3 days preincubation. Endothelial cells treated with 1 microM 4-HPR fails to form tubes, but forms small cellular aggregates.

Fenretinide (4-HPR) (10 mg/kg, i.p.) selectively inhibits ceramide accumulation HFD-fed male C57Bl/6 mice. Fenretinide treatment improves glucose tolerance and insulin sensitivity as determined by both glucose and insulin tolerance tests. Addition of 25 mg/kg ketoconazole to Fenretinide in NOD/SCID mice increased 4-HPR plasma levels.

产品供应商
Fenretinide
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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