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CAS号:6211-32-1
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英文名称:Rauwolscine hydrochloride
分子式
C21H27ClN2O3
分子量
391
EINECS号
228-279-6
MDL
MFCD00069342
Smiles
InChIKey
乙二醇化学百科
基本信息
物化性质
安全信息
生产及用途
Rauwolscine hydrochloride是高效,选择性的 α2 adrenergic 受体拮抗剂,Ki 值为12 nM。
[ 3 H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [ 3 H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [ 3 H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [ 3 H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (K i human=14.3 nM, K i rat=35.8 nM). Saturation studies shows that the affinity of [ 3 H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .
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