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缓激肽
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CAS号:58-82-2 | 英文名称:Bradykinin
分子式 C50H73N15O11
分子量 1060
EINECS号 200-398-8
MDL MFCD00076258
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 BK
英文名称 BRADYKININ
CAS号 58-82-2
分子式 C50H73N15O11
分子量 1060.21
EINECS号 200-398-8
物化性质
熔点 170°C (rough estimate)
比旋光度 D25 -76.5° (c = 1.37 in 1N acetic acid)
沸点 811.85°C (rough estimate)
密度 1.1171 (rough estimate)
折射率 1.6930 (estimate)
溶解度 H2O: >40 mg/mL
形态 白色至灰白色冻干固体
酸度系数(pKa) 3.34±0.10(Predicted)
颜色 冻干粉
水溶解性 Soluble to 1 mg/ml in water.
安全信息
安全说明 22-24/25
WGK Germany 3
RTECS号 EE1530000
F 3-10-23
生产及用途
Bradykinin是由激肽释放酶-激肽系统产生的活性肽。 它是炎症调节因子,也被认为是几种血管和肾功能以及神经调节因子。

Human Endogenous Metabolite

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF. Bradykinin has been reported to be involved in the progression of many types of cancer. Bradykinin treatment promotes the invasion and migration of colorectal cancer cells. Bradykinin treatment stimulates ERK1/2 activation and IL-6 production. Exogenous bradykinin markedly inhibits TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. The NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolish the inhibitory effects of bradykinin on tissue factor expression.

Application of 1 μM bradykinin to the ovary produces significant decreases in heart rate and mean arterial pressure. In vagotomized animals, application of 1 μM bradykinin to the ovary produces bradycardia and hypotension similar to the responses evoked when vagal innervation is intact. Vascular bradykinin can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin treatment group increases gradually after 48 h. PI3K/Akt signaling pathway activation induced by bradykinin administration reduces the activity of GSK-3β and MAPK, and reduces NF-x03BA;B level in the nucleus, thereby inhibiting TF expression. Consistent with this, intraperitoneal injection of C57/BL6 mice with bradykinin also inhibits the thrombus formation induced by ligation of inferior vena cava.

参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
类别
有毒物品
毒性分级
剧毒
急性毒性
腹腔-大鼠 TDL0:0.00053 毫克/公斤;静脉-大鼠TDL0:0.000212毫克/公斤
可燃性危险特性
热分解排出有毒氮氧化物气体
储运特性
库房通风, 低温, 干燥, 密闭, 与食品原料分开存放
灭火剂
水,泡沫,沙土,二氧化碳,干粉
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