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CAS号:526-31-8
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英文名称:L-ABRINE
分子式
C12H14N2O2
分子量
218
EINECS号
208-388-5
MDL
MFCD00005645
Smiles
C(O)(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC
InChIKey
CZCIKBSVHDNIDH-NSHDSACASA-N
乙二醇化学百科
基本信息
物化性质
安全信息
生产及用途
L-Abrine (N-Methyl-L-tryptophan)是相思子根部的毒性清蛋白,可抑制核糖体。 L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.
Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD 50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD 50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.
用途 一种在体外表现出自由基清除和抗氧化剂特性的吲哚氨基酸。
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