CAS号：479-50-5
|
英文名称：lucanthone
分子式
C20H24N2OS
分子量
340
EINECS号
207-532-4
MDL
MFCD00866726
Smiles
InChIKey
硫坎酮化学百科
基本信息
| 中文名称 | 硫坎酮 |
| 英文名称 | lucanthone |
| CAS号 | 479-50-5 |
| 分子式 | C20H24N2OS |
| 分子量 | 340.48 |
| EINECS号 | 207-532-4 |
物化性质
| 熔点 | 64.5°C |
| 沸点 | 512.4±50.0 °C(Predicted) |
| 密度 | 1.0915 (rough estimate) |
| 折射率 | 1.5950 (estimate) |
| 溶解度 | 二甲基亚砜：25 mg/mL（73.43 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.00±0.25(Predicted) |
| 颜色 | 米白色至橙色 |
安全信息
生产及用途
Lucanthone是新型的自噬抑制剂，也是可用于口服的DNA嵌入剂、DNA修复酶APE1的抑制剂。
APE-1
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC 50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.
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