CasImg
5-甲氧基黄酮
产品纠错
CAS号:42079-78-7 | 英文名称:5-METHOXYFLAVONE
分子式 C16H12O3
分子量 252
EINECS号 255-652-0
MDL MFCD00016942
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 5-甲氧基黄酮
英文名称 5-METHOXYFLAVONE
CAS号 42079-78-7
分子式 C16H12O3
分子量 252.26
EINECS号 255-652-0
物化性质
熔点 131-133°C
沸点 422.5±45.0 °C(Predicted)
密度 1,155g/cm
折射率 1,548
LogP 3.470 (est)
溶解度 溶于甲醇
形态 粉末晶体
颜色 白色到近乎白色
安全信息
危险品标志 Xi
危险类别码 36/37/38
安全说明 26-36/37/39-36
WGK Germany 3
海关编码 2932.99.7000
生产及用途
5-Methoxyflavone,是一种类黄酮,是DNA聚合酶 β (DNA polymerase-beta) 的抑制剂和 β-淀粉样蛋白毒性的神经保护剂。拥有中枢神经系统镇静剂的作用,通过调控嗜离子 GABAA 受体来实现。
TargetValue
DNA polymerase β
()

5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. 5-methoxyflavone (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF, 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner.

5-Methoxyflavone (100, 150 mg/kg, i.p) significantly decreases the latency time to loss of righting reflex. 5-Methoxyflavone (50, 100 and 150 mg/kg, i.p) exhibits a significant and dose-dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, i.p) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, i.p) completely abolishesed the grooming response similar to diazepam treated animals.

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产品供应商
5-Methoxyflavone
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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