甲醇中菲诺特罗溶液标准物质 Fenoterol hydrobromide CAS#:1944-12-3

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甲醇中菲诺特罗溶液标准物质

产品纠错

CAS号：1944-12-3 | 英文名称：Fenoterol hydrobromide

分子式 C₁₇H₂₂BrNO₄

分子量 384

EINECS号 217-742-8

MDL MFCD00079288

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	氢溴酸非诺特罗
英文名称	FENOTEROL HYDROBROMIDE
CAS号	1944-12-3
分子式	C17H21NO4.BrH
分子量	384.27
EINECS号	217-742-8

物化性质

熔点	226-228°C
溶解度	溶于水和乙醇（96%）。
形态	固体
颜色	白色至类白色

安全信息

危险品标志	Xn
危险类别码	22
安全说明	36
危险品运输编号	3249
WGK Germany	3
RTECS号	DO1500000
海关编码	29225090
危险等级	6.1(b)
包装类别	III
毒性	LD50 in mice (mg/kg): 1100 s.c.; 1990 orally (Goldenthal)

生产及用途

生物活性

Fenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。

靶点

Target	Value
β2 adrenoreceptor ()

体外研究

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.

Western Blot Analysis

Cell Line:	THP-1 cells stimulated with AICAR
Concentration:	1 μM
Incubation Time:	Pre-incubated 30 minutes
Result:	Significantly downregulated the elevated phosphorylation levels of AMPK.

体内研究

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.

Animal Model:	Male C57BL/6J mice (6 weeks old) with neuropathy
Dosage:	0.7 mg/kg
Administration:	Intraperitoneal injection; twice a day; for 3 weeks
Result:	Alleviated neuropathic allodynia during chronic treatment.

用途

校准仪器和装置；评价方法；工作标准；质量保证/质量控制

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