CAS号：13392-18-2
|
英文名称：Fenoterol
分子式
C17H21NO4
分子量
303
EINECS号
MDL
MFCD00242675
Smiles
InChIKey
非诺特罗化学百科
基本信息
| 中文名称 | 非诺特罗 |
| 英文名称 | Fenoterol |
| CAS号 | 13392-18-2 |
| 分子式 | C17H21NO4 |
| 分子量 | 303.35 |
| EINECS号 | 680-817-2 |
物化性质
| 熔点 | 181-183°C |
| 沸点 | 566.0±45.0 °C(Predicted) |
| 密度 | 1.289±0.06 g/cm3(Predicted) |
| 形态 | 固体 |
| 酸度系数(pKa) | pKa 8.5 (Uncertain);10.0 (Uncertain) |
| 颜色 | 浅棕色至棕色 |
安全信息
生产及用途
Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂，具有支气管扩张活性。
| Target | Value |
|
β2 adrenoreceptor
() |
Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.
Western Blot Analysis
| Cell Line: | THP-1 cells stimulated with AICAR |
| Concentration: | 1 μM |
| Incubation Time: | Pre-incubated 30 minutes |
| Result: | Significantly downregulated the elevated phosphorylation levels of AMPK. |
Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.
| Animal Model: | Male C57BL/6J mice (6 weeks old) with neuropathy |
| Dosage: | 0.7 mg/kg |
| Administration: | Intraperitoneal injection; twice a day; for 3 weeks |
| Result: | Alleviated neuropathic allodynia during chronic treatment. |
上下游产品
相关产品
-
CAS号:1944-12-3
甲醇中菲诺特罗溶液标准物质 -
CAS号:95266-40-3
抗倒酯（标准品） , 100 μg/mL in Methanol -
CAS号:586-06-1
奥西那林 -
CAS号:3571-71-9
美他特罗 -
CAS号:64-17-5
乙醇 -
CAS号:19430-83-2
3,4'-二氨基二苯基甲烷 -
CAS号:74-84-0
乙烷 -
CAS号:2809-21-4
羟基乙叉二膦酸(HEDP) -
CAS号:120-47-8
尼泊金乙酯 -
CAS号:76-16-4
六氟乙烷 -
CAS号:163520-33-0
双苯恶唑酸 -
CAS号:110-80-5
乙二醇乙醚 -
CAS号:141-78-6
乙酸乙酯 , 99.9% , 超干溶剂, 带分子筛, J&KSeal瓶 -
CAS号:77-86-1
三(羟甲基)氨基甲烷 -
CAS号:137234-87-8
4-乙基-5-氟-6-羟基嘧啶 -
CAS号:1914-99-4
偶氮氯膦Ⅲ -
CAS号:1944-12-3
甲醇中菲诺特罗溶液标准物质 -
CAS号:95266-40-3
抗倒酯（标准品） , 100 μg/mL in Methanol -
CAS号:586-06-1
奥西那林 -
CAS号:3571-71-9
美他特罗 -
CAS号:64-17-5
乙醇 -
CAS号:19430-83-2
3,4'-二氨基二苯基甲烷 -
CAS号:74-84-0
乙烷 -
CAS号:2809-21-4
羟基乙叉二膦酸(HEDP) -
CAS号:120-47-8
尼泊金乙酯 -
CAS号:76-16-4
六氟乙烷 -
CAS号:163520-33-0
双苯恶唑酸 -
CAS号:110-80-5
乙二醇乙醚 -
CAS号:141-78-6
乙酸乙酯 , 99.9% , 超干溶剂, 带分子筛, J&KSeal瓶 -
CAS号:77-86-1
三(羟甲基)氨基甲烷 -
CAS号:137234-87-8
4-乙基-5-氟-6-羟基嘧啶 -
CAS号:1914-99-4
偶氮氯膦Ⅲ
产品供应商