非诺特罗 Fenoterol CAS#:13392-18-2

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CAS号：13392-18-2 | 英文名称：Fenoterol

分子式 C₁₇H₂₁NO₄

分子量 303

EINECS号

MDL MFCD00242675

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	非诺特罗
英文名称	Fenoterol
CAS号	13392-18-2
分子式	C17H21NO4
分子量	303.35
EINECS号	680-817-2

物化性质

熔点	181-183°C
沸点	566.0±45.0 °C(Predicted)
密度	1.289±0.06 g/cm3(Predicted)
形态	固体
酸度系数(pKa)	pKa 8.5 (Uncertain);10.0 (Uncertain)
颜色	浅棕色至棕色

安全信息

生产及用途

生物活性

Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂，具有支气管扩张活性。

靶点

Target	Value
β2 adrenoreceptor ()

体外研究

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.

Western Blot Analysis

Cell Line:	THP-1 cells stimulated with AICAR
Concentration:	1 μM
Incubation Time:	Pre-incubated 30 minutes
Result:	Significantly downregulated the elevated phosphorylation levels of AMPK.

体内研究

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.

Animal Model:	Male C57BL/6J mice (6 weeks old) with neuropathy
Dosage:	0.7 mg/kg
Administration:	Intraperitoneal injection; twice a day; for 3 weeks
Result:	Alleviated neuropathic allodynia during chronic treatment.

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