L-Palmitoylcarnitine (1 µM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC ₅₀ fell from 62 to 30 µM).
Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the K _ATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2.