锌原卟啉 PROTOPORPHYRINATO ZINC CAS#:15442-64-5

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锌原卟啉

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CAS号：15442-64-5 | 英文名称：PROTOPORPHYRINATO ZINC

分子式 C₃₄H₃₁N₄O₄Zn-

分子量 625

EINECS号 239-455-7

MDL MFCD00011612

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	锌原卟啉
英文名称	PROTOPORPHYRINATO ZINC
CAS号	15442-64-5
分子式	C34H31N4O4Zn-
分子量	625.03
EINECS号	239-455-7

物化性质

溶解度	DMSO：50 mg/mL（79.87 mM；需要超声波）H2O：< 0.1 mg/mL（不溶）
形态	结晶
颜色	暗红色至紫色
水溶解性	Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide.
稳定性	吸湿性

安全信息

WGK Germany	3
RTECS号	ZG9210300
TSCA	Yes

生产及用途

生物活性

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的，竞争性的血红素加氧酶-1 (HO-1) 抑制剂，显着减弱间苯三酚 (PG) 对 H2O2 的保护作用。Zinc Protoporphyrin 可用作个体孕妇和儿童缺铁的筛查标志物，也用于评估人群铁状态与血红蛋白浓度的组合。Zinc Protoporphyrin 具有抗癌活性。

靶点

Human Endogenous Metabolite

体外研究

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.

Apoptosis Analysis

Cell Line:	C-26 cells
Concentration:	5 μM
Incubation Time:	72 hours
Result:	The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h.

Cell Cytotoxicity Assay

Cell Line:	C-26 and MDA-MB231 cells
Concentration:	1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time:	48 or 72 hours
Result:	Exerted cystostatic/cytotoxic effects against tumor cells.

Cell Cycle Analysis

Cell Line:	C-26 cells
Concentration:	2.5, 5 μM
Incubation Time:	48 or 72 hours
Result:	Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.

Western Blot Analysis

Cell Line:	C-26 cells
Concentration:	1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time:	48 hours
Result:	Leaded to accumulation of cleaved (active) caspase-3.

体内研究

Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.

Animal Model:	BALB/c mice inoculated with C-26 cells
Dosage:	12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.
Administration:	IP or PO; from day 7 to 19
Result:	Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.

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