CasImg
罗丹明110
产品纠错
CAS号:13558-31-1 | 英文名称:3,6-diamino-9-(2-carboxyphenyl)xanthylium chloride
分子式 C20H15ClN2O3
分子量 367
EINECS号 236-944-7
MDL MFCD00042009
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 罗丹明
英文名称 RHODAMINE 110
CAS号 13558-31-1
分子式 C20H15ClN2O3
分子量 366.8
EINECS号 236-944-7
物化性质
熔点 >300 °C(lit.)
密度 1.2504 (rough estimate)
折射率 1.6470 (estimate)
溶解度 可溶于乙醇
形态 结晶粉末
颜色 白色至浅黄色至浅橙色
最大波长(λmax) 499nm (MeOH); 496nm (H2O)
BRN 4631860
稳定性 有吸湿性、光敏性
生物领域应用 Detecting risk of Alzheimer’s disease and stroke;evaluating/testing sperm quality; identifying bacteria; as a substrate for measuring aromatase activity, azoreductase activity,phospholipase activity, proteases activity (caspase activity, cathepsin C activity, elastase activity proteinase activity);implantable drug-delivery devices
主要应用 Color filters; liquid crystal displays; dye lasers;electroluminescent displays;inks;light-emitting diode (LED);papermaking process; recording materials; solar cells; silica thin films;sol–gel titania films;waveguides
安全信息
危险品标志 Xn
危险类别码 22
安全说明 22-24/25-36/37/39-26
WGK Germany 3
海关编码 29329990
生产及用途
罗丹明类探针的优点是内酰胺环打破了氧杂蒽的π共轭,导致极低的吸收和荧光背景;在分析物的作用下,开环后可以恢复罗丹明的颜色和荧光,实现高信号/背景比分析。但是衍生物开环后通常在500 ~ 550 nm处出现最大吸收峰,在520 ~ 580 nm处发出荧光,这对于生物成像来说波长相对较短。Rhodamine 110 是一种灵敏和选择性的底物 (substrate),用于测定溶液或活细胞内的蛋白酶。激发波长为 498 nm,发射波长为 521 nm。

Rhodamine 110 accumulates in mitochondria in a cationic form, which alters the pH in this cellular compartment. Rhodamine 110 accumulates in human lymphoblastoid cells and Friend leukemia cells. No cytotoxicity to human lymphoblastoid cells is observed below 10 μM, but Rhodamine 110 causes Friend leukemia cells to die at a concentrations above 100 μM.

Rhodamine 110 is less toxic than the parent molecule based on the intravenous LD 50 acute toxicity values of 89.5 mg/kg and 140.0 mg/kg for Rhodamine B and Rhodamine 110, respectively. Both molecules induce liver and kidney enlargement after ingestion, and male rats show more significant increases than female rats after Rhodamine 110 exposure. In addition, testis weight increased in male rats dosed with Rhodamine 110. The pharmacokinetics of Rhodamine 110 are assessed following oral administration at two dosages (3 and 10 mg/kg) and intravenous administration at one dosage (3 mg/kg). Pharmacokinetic parameters are calculated using an extravascular input and IV-bolus input, noncompartmental model analysis conducted with WinNonlin Standard Edition. The pharmacokinetic parameters of Rhodamine 110 indicates that the maximum plasma concentrations (C max ) of the two oral dosages are 283.4 and 657.0 ng/mL, which are reached at 140 and 210 min, respectively. This indicates that Rhodamine 110 absorption is not rapid after ingestion, as it took over 2 h to be absorbed from the intestines into the blood. The areas under the concentration–time curves (AUCs) for the two dosages are 138.1±20.3 and 444.0±170.8 h ng/mL. The pharmacokinetic data demonstrate that the AUC is proportional to the administered oral dose of Rhodamine 110 (3 mg/kg and 10 mg/kg). Furthermore, the clearance (Cl) of the two orally administered doses is 7.94 and 8.61 mL/min/kg, respectively.

用途 
激光染料。
产品供应商
Rhodamine 110 chloride
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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