CasImg
蓝色染料
产品纠错
CAS号:12236-82-7 | 英文名称:REACTIVE BLUE 2
分子式 C29H20ClN7O11S3
分子量 774
EINECS号 235-465-0
MDL MFCD00043102
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 兰色染料
英文名称 REACTIVE BLUE 2
CAS号 12236-82-7
分子式 C29H20ClN7O11S3
分子量 774.16
EINECS号 235-465-0
物化性质
溶解度 可溶于水中
形态 生理盐水悬浮液
颜色 深蓝
稳定性 稳定的。与强氧化剂不相容。
安全信息
危险品标志 Xi
危险类别码 36/37/38
安全说明 26-36
WGK Germany 3
F 10-21
生产及用途
Procion Blue HB (Reactive Blue 2)是嘌呤能拮抗剂。

Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca 2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca 2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca 2+ -dependent manner and induce Ca 2+ oscillations. The application of Reactive Blue 2 increases K + secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion.The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a K i of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner.

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