CasImg
丙咪嗪盐酸盐
产品纠错
CAS号:113-52-0 | 英文名称:Imipramine hydrochloride
分子式 C19H25ClN2
分子量 317
EINECS号 204-030-7
MDL MFCD00012669
Smiles N1(CCCN(C)C)C2=CC=CC=C2CCC2C=CC=CC1=2.Cl
InChIKey XZZXIYZZBJDEEP-UHFFFAOYSA-N
乙二醇化学百科
基本信息
中文名称 盐酸丙咪嗪
英文名称 Imipramine hydrochloride
CAS号 113-52-0
分子式 C19H25ClN2
分子量 316.87
EINECS号 204-030-7
物化性质
熔点 168-1700C
闪点 9℃
溶解度 H2O:50 mg/mL
形态 结晶
颜色 白色
PH值 4.2~5.2(100g/l,25℃)
水溶解性 Soluble in water
最大波长(λmax) 260nm(lit.)
Merck 14,4920
安全信息
危险品标志 Xn,T,F
危险类别码 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11
安全说明 7-16-24-33-45-36-26-36/37
危险品运输编号 UN 1230 3/PG 2
WGK Germany 3
RTECS号 HO1925000
TSCA Yes
海关编码 2933995800
毒性 LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)
生产及用途
Imipramine hydrochloride 抑制血清素转运蛋白(serotonin),IC50 值为 32 nM。Imipramine hydrochloride 可阻止胰酶的易位,抑制 MV 和外泌体的分泌。

IC50: 32 nM (serotonin)

Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC 50 =32 nM) and desipramine (IC 50 =160 nM) are found to be potent inhibitors of the human placental serotonin transporter.

Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor.

化学性质 
白色结晶性粉末。熔点174-175℃。易溶于水、乙醇,微溶于丙酮,几乎不溶于乙醚。无臭,味苦。遇光渐变色。米帕明碱([50-49-7])沸点160℃(13.3Pa)。
用途 
镇静安眠性抗组织胺及抗抑郁药,治疗精神抑郁症及小儿遗尿症。
用途 
用于治疗各种类型抑郁症、小儿遗尿症等
生产方法 
10,11-二氢-5-二苯并[b,f]氮杂卓(见14230)与甲苯、钠氨一起加热回流1h,冷至40-50℃,滴加1-氯-3-二甲氨基丙烷,再回流16h。冷却,过滤,滤液水洗层,取甲苯层减压蒸馏,回收甲苯后,收集210-230℃(0.67kPa)馏分,得米帕明碱,最后经成盐而得成品。
产品供应商
Imipramine Hydrochloride
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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