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磺胺氯吡嗪钠
产品纠错
CAS号:102-65-8 | 英文名称:Sulfaclozine
分子式 C10H9ClN4O2S
分子量 285
EINECS号 203-044-0
MDL MFCD00868569
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 磺胺氯吡嗪钠
英文名称 N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO
CAS号 102-65-8
分子式 C10H9ClN4O2S
分子量 284.72
EINECS号 203-044-0
物化性质
熔点 234.8-235.4 °C
沸点 495.7±55.0 °C(Predicted)
密度 1.588±0.06 g/cm3(Predicted)
溶解度 DMSO(轻微)、甲醇(轻微、加热、超声处理)
形态 固体
酸度系数(pKa) 4.83±0.10(Predicted)
颜色 白色至类白色
安全信息
生产及用途
Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一种抗原生动物药,用于球虫病的研究。

Bacterial; Parasite

The elimination of Sulfaclozine in the three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 . Sulfaclozine is weakly adsorbed on the surface of TiO 2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of OH and SO 4 •− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.

Animal Model: 14 male broiler chickens (30-day-old)
Dosage: 60 mg/kg
Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
用途 
磺胺氯吡嗪钠为抗球虫的专用磺胺药,广泛用于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成,从而抑制细菌和球虫的生长繁殖。本品对家禽球虫的作用特点与磺胺喹沙啉相似,但具更强的抗菌作用,甚至可治疗禽霍乱及鸡伤寒因此最适合球虫病爆发时治疗用。
用途 
本品为抗球虫的专用磺胺药,广泛用于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成,从而抑制细菌和球虫的生长繁殖。本品对家禽球虫的作用特点与磺胺喹沙啉相似,但具更强的抗菌作用,甚至可治疗禽霍乱及鸡伤寒因此最适合球虫病爆发时治疗用。
用途 
磺胺类抗菌药,用于禽畜大肠杆菌和巴式杆菌感染,与甲氧苄啶与蔗糖配置而成复方磺胺氯哒嗪钠盐效果更加,对磺胺类药过敏者忌用,肾功能减退者慎用。
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产品供应商
Sulfalozine
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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