磺胺氯吡嗪钠 Sulfaclozine CAS#:102-65-8

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首页化工产品目录原料药抗寄生虫病药抗原虫药磺胺氯吡嗪钠

磺胺氯吡嗪钠

产品纠错

CAS号：102-65-8 | 英文名称：Sulfaclozine

分子式 C₁₀H₉ClN₄O₂S

分子量 285

EINECS号 203-044-0

MDL MFCD00868569

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	磺胺氯吡嗪钠
英文名称	N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO
CAS号	102-65-8
分子式	C10H9ClN4O2S
分子量	284.72
EINECS号	203-044-0

物化性质

熔点	234.8-235.4 °C
沸点	495.7±55.0 °C(Predicted)
密度	1.588±0.06 g/cm3(Predicted)
溶解度	DMSO（轻微）、甲醇（轻微、加热、超声处理）
形态	固体
酸度系数(pKa)	4.83±0.10(Predicted)
颜色	白色至类白色

安全信息

生产及用途

生物活性

Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一种抗原生动物药，用于球虫病的研究。

靶点

Bacterial; Parasite

体外研究

The elimination of Sulfaclozine in the three systems: UV/TiO ₂ , UV/K ₂ S ₂ O ₈ , and UV/TiO ₂ /K ₂ S ₂ O ₈ . Sulfaclozine is weakly adsorbed on the surface of TiO ₂ at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO ₂ , UV/K ₂ S ₂ O ₈ , and UV/TiO ₂ /K ₂ S ₂ O ₈ in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of ^• OH and SO ₄ ^•− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.

体内研究

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.

Animal Model:	14 male broiler chickens (30-day-old)
Dosage:	60 mg/kg
Administration:	Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result:	Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.