白头翁皂苷D Pulsatilla saponin d CAS#:68027-15-6

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白头翁皂苷D

产品纠错

CAS号：68027-15-6 | 英文名称：Pulsatilla saponin d

分子式

分子量

EINECS号

MDL

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
英文名称	Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
CAS号	68027-15-6
分子式	C47H76O17
分子量	913.09614
EINECS号	211-708-6

物化性质

熔点	239-241℃
沸点	997.6±65.0 °C(Predicted)
密度	1.40±0.1 g/cm3 (20 ºC 760 Torr)
溶解度	少许溶于甲醇、可溶于吡啶
形态	固体
酸度系数(pKa)	4.63±0.70(Predicted)
颜色	白色至浅米色

安全信息

生产及用途

生物活性

Pulsatilla saponin D (SB365) 可从 Pulsatilla koreana Nakai 根部分离得到，具有抗癌活性。

靶点

Target	Value
c-Met ()

体外研究

Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase.
Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells.
Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) .
Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.
Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells.

Cell Cytotoxicity Assay

Cell Line:	A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells.
Concentration:	0.3 ng/mL to 10 μg/mL.
Incubation Time:	72 h.
Result:	Exhibited an ED ₅₀ value of 6.3 μg/mL for A-549 cells.

体内研究

Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model.

Animal Model:	2x2x2 mm ³ tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice.
Dosage:	6.4 mg/kg.
Administration:	Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day.
Result:	Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%).

化学性质

白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白头翁。

用途

白头翁皂苷D具有抗菌，抗肿瘤，镇静，镇痛的作用。

用途

药理药效:抗菌，抗肿瘤，镇静，镇痛

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