CAS号：65836-72-8
|
英文名称：2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
分子式
C11H14ClNO3
分子量
244
EINECS号
604-604-1
MDL
MFCD01733639
Smiles
InChIKey
2-Chloro-N-(3,4-dimethoxybenzyl)acetamide化学百科
基本信息
| 中文名称 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE |
| 英文名称 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE |
| CAS号 | 65836-72-8 |
| 分子式 | C11H14ClNO3 |
| 分子量 | 243.69 |
| EINECS号 | 604-604-1 |
物化性质
| 熔点 | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) |
| 沸点 | 425.7±45.0 °C(Predicted) |
| 密度 | 1.194±0.06 g/cm3(Predicted) |
| 溶解度 | 二甲基亚砜：≥150mg/mL（615.54mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.42±0.46(Predicted) |
| 颜色 | 白色至浅黄色 |
安全信息
| 危险品标志 | Xi |
| 危险等级 | IRRITANT |
生产及用途
DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
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