CasImg
阿维菌素
产品纠错
CAS号:65195-55-3 | 英文名称:Abamectin
分子式 C48H72O14
分子量 873
EINECS号 265-610-3
MDL MFCD01939385
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 阿维菌素 B1a
英文名称 Avermectin B1a
CAS号 65195-55-3
分子式 C48H72O14
分子量 873.09
EINECS号 265-610-3
物化性质
沸点 940.9±65.0 °C(Predicted)
密度 1.24±0.1 g/cm3(Predicted)
溶解度 DMSO 中≥143.4 mg/mL; ≥11.86 mg/mL,乙醇溶液,超声波;不溶于水
形态 粉末
酸度系数(pKa) 12.42±0.70(Predicted)
颜色 白色至浅黄色
稳定性 吸湿性
安全信息
危险品运输编号 2588
危险等级 6.1(a)
包装类别 II
毒性 LD20 orl-rat: 10 mg/kg JAFCAU 32,94,84
生产及用途
Avermectin B1a 是一种抗寄生虫剂,能够使线虫瘫痪。

[ 3 H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [ 3 H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [ 3 H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [ 3 H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC 50 values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations.

Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD 50 ) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm 2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms.

类别
有毒物品
毒性分级
高毒
急性毒性
口服-大鼠 LD20: 10 毫克/公斤; 口服-小鼠 LD50: 19 毫克/公斤
可燃性危险特性
可燃; 燃烧产生刺激烟雾
储运特性
通风低温干燥
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
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