CAS号：5122-36-1
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英文名称：FAPy-adenine
分子式
C5H7N5O
分子量
153
EINECS号
200-258-5
MDL
MFCD00047382
Smiles
InChIKey
4,6-二氨基-5-(甲酰氨基)嘧啶化学百科
基本信息
| 中文名称 | 4,6-二氨基-5-甲酰胺基嘧啶 |
| 英文名称 | 4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE |
| CAS号 | 5122-36-1 |
| 分子式 | C5H7N5O |
| 分子量 | 153.14 |
| EINECS号 | 200-258-5 |
物化性质
| 熔点 | 224-226 °C |
| 沸点 | 536.1±50.0 °C(Predicted) |
| 密度 | 1.575±0.06 g/cm3(Predicted) |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.35±0.70(Predicted) |
| 颜色 | 米白色至浅黄色 |
安全信息
| WGK Germany | 3 |
生产及用途
FAPy-adenine 是一种氧化的 DNA 碱基。FAPy-adenine 在阿尔茨海默病脑中呈上升趋势。氧化核苷是肿瘤、衰老和神经退行性疾病的生化标志物。
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Human Endogenous Metabolite
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In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine.
The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease.
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