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首页 化工产品目录 PJ34(游离)
344458-19-1
PJ34(游离)
产品纠错
CAS号:344458-19-1 | 英文名称:PJ34
分子式 C17H17N3O2
分子量 295
EINECS号 604-604-1
MDL MFCD17014689
Smiles
InChIKey
PJ34(游离)化学百科
基本信息
中文名称 PJ-34
英文名称 PJ-34
CAS号 344458-19-1
分子式 C17H17N3O2
分子量 295.34
EINECS号 604-604-1
物化性质
溶解度 溶于二甲基亚砜
形态 固体
颜色 浅黄至卡其色
安全信息
生产及用途
PJ34 是一种有效的特异性 PARPl/2 抑制剂,IC50 分别为 110 nM 和 86 nM。

PARP

110 nM (IC 50 )

PARP-2

86 nM (IC 50 )

PARP-1

110 nM (IC 50 )

PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M.

To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.

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