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盐酸替诺立定
产品纠错
CAS号:25913-34-2 | 英文名称:ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride
分子式 C17H21ClN2O2S
分子量 353
EINECS号 247-342-9
MDL MFCD01680536
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 盐酸替诺立定
英文名称 ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride
CAS号 25913-34-2
分子式 C17H21ClN2O2S
分子量 352.87884
EINECS号 247-342-9
物化性质
熔点 234-235° (dec)
溶解度 二甲基亚砜:≥31mg/mL(87.85mM)
形态 固体
颜色 白色至黄色
安全信息
毒性 LD50 orally in mice: 1601 mg/kg (Nakanishi, 1974)
生产及用途
Tinoridine hydrochloride (Y-3642)是一种非类固醇的消炎药物,具有有效的抗氧化活性。

Tinoridine reduces a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1:2, indicating its free radical scavenging ability. Tinoridine inhibits the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe 2+ , in which hydroxyl radical is formed. Tinoridine is demonstrated to be oxidized in the course of the lipid peroxidation by following the fluorescence derived from the oxidation product of tinoridine. It is also oxidized by the xanthine-xanthine oxidase system in the presence of Fe 2+ , but its oxidation is slow in the absence of Fe 2+ and almost completely inhibited by catalase. Tinoridine is also oxidized by H 2 O 2 -Fe 2+ system producing OH (Fenton reaction), but it does not affect the reduction of cytochrome c caused by superoxide radical.

CCl 4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl 4 -induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed.

类别
有毒物品
毒性分级
中毒
急性毒性
口服-大鼠LD50: 1200 毫克/公斤;口服-小鼠LD50:1601 毫克/公斤
可燃性危险特性
可燃;燃烧产生有毒氮氧化物, 硫氧化物和氯化氢烟雾
储运特性
库房通风低温干燥
灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水
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