|
||||||||||||||||||||||
![]()
CAS号:25913-34-2
|
英文名称:ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride
分子式
C17H21ClN2O2S
分子量
353
EINECS号
247-342-9
MDL
MFCD01680536
Smiles
InChIKey
乙二醇化学百科
基本信息
物化性质
安全信息
生产及用途
Tinoridine hydrochloride (Y-3642)是一种非类固醇的消炎药物,具有有效的抗氧化活性。 Tinoridine reduces a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1:2, indicating its free radical scavenging ability. Tinoridine inhibits the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe 2+ , in which hydroxyl radical is formed. Tinoridine is demonstrated to be oxidized in the course of the lipid peroxidation by following the fluorescence derived from the oxidation product of tinoridine. It is also oxidized by the xanthine-xanthine oxidase system in the presence of Fe 2+ , but its oxidation is slow in the absence of Fe 2+ and almost completely inhibited by catalase. Tinoridine is also oxidized by H 2 O 2 -Fe 2+ system producing OH (Fenton reaction), but it does not affect the reduction of cytochrome c caused by superoxide radical.
CCl 4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl 4 -induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed.
类别 有毒物品毒性分级 中毒急性毒性 口服-大鼠LD50: 1200 毫克/公斤;口服-小鼠LD50:1601 毫克/公斤可燃性危险特性 可燃;燃烧产生有毒氮氧化物, 硫氧化物和氯化氢烟雾储运特性 库房通风低温干燥灭火剂 干粉、泡沫、砂土、二氧化碳, 雾状水
上下游产品
上游产品共计:0个
下游产品共计:0个
产品供应商
|
||||||||||||||||||||||