| 中文名称 | CP 465022 HYDROCHLORIDE |
| 英文名称 | 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride |
| CAS号 | 199655-36-2 |
| 分子式 | C26H24ClFN4O |
| 分子量 | 462.95 |
| EINECS号 | 200-158-5 |
| 沸点 | 585.0±60.0 °C(Predicted) |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 溶解度 | 不溶于水； <49.94mg/ml，溶于 DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.51±0.25(Predicted) |
| 颜色 | 粘黄色 |
IC50: 25 nM (rat cortical neurons)
CP-465022 (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC 50 of 25 nM and essentially complete inhibition at 3.2 µM. CP-465022 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP-465022 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons.CP-465022 (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%).