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医药中间体
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有机原料
原料药
染料及颜料
表面活性剂
香精与香料
化学试剂
食品添加剂
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分析化学
170809-51-5
ASTRESSIN
产品纠错
CAS号:170809-51-5 | 英文名称:ASTRESSIN
分子式 C161H269N49O42
分子量 3563
EINECS号 617-559-7
MDL MFCD00798715
Smiles
InChIKey
ASTRESSIN化学百科
基本信息
中文名称 ASTRESSIN
英文名称 ASTRESSIN
CAS号 170809-51-5
分子式 C161H269N49O42
分子量 3563.16
EINECS号 617-559-7
物化性质
密度 1.43±0.1 g/cm3(Predicted)
形态 粉末
颜色 白色至米白色
水溶解性 Soluble to 1 mg/ml in 10% Acetic acid / water
安全信息
WGK Germany 3
生产及用途
Astressin是有效的促肾上腺皮质激素释放因子 (CRF) 拮抗剂。

Astressin has low affinity for the CRF binding protein and high affinity (K i =2 nM) for the cloned pituitary receptor. Astressin shows high affinity for cloned human CRF-RA1 stably expressed in CHO cells and high potency to inhibit ACTH secretion.

Astressin is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin (ACTH) secretion in stressed or adrenalectomized rats. Low doses of astressin (30 μg and 100 μg per kg) administered i.v. still produce a significant decrease in ACTH levels at 45 and 90 min, respectively. Astressin significantly reverses the anxiogenic-like response induced by both social stress and ICV rat/humanCRF (r/hCRF) on the elevated plus-maze, but fails to block the effects of r/hCRF-induced locomotor activity in a familiar environment. Intracerebroventricular infusion of the peptide both 30 min before and 10 min after seizures decreases damage in some hippocampal cell fields by as much as 84%, a magnitude of protection greater than reported for other CRF antagonists against other models of necrotic neuronal injury. Astressin protects even if administered only 10 min following excitotoxin exposure.

参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
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