CasImg
伐司扑达
产品纠错
CAS号:121584-18-7 | 英文名称:Valspodar
分子式 C63H111N11O12
分子量 1215
EINECS号 1312995-182-4
MDL MFCD00907207
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 伐司扑达
英文名称 Valspodar
CAS号 121584-18-7
分子式 C63H111N11O12
分子量 1214.62
EINECS号 1312995-182-4
物化性质
熔点 143-145°C
比旋光度 D20 -255.1° (c = 0.5 in CHCl3)
沸点 1290.1±65.0 °C(Predicted)
密度 1.015±0.06 g/cm3(Predicted)
溶解度 可溶于氯仿(少许)、甲醇(少许)
形态 粉末
酸度系数(pKa) 12.45±0.70(Predicted)
颜色 白色至米色
安全信息
WGK Germany 3
生产及用途
Valspodar (PSC 833) 是一种选择性的 P-糖蛋白抑制剂,已被用作化学增敏剂用于实验性癌症的研究。

Valspodar (PSC 833) has no cytotoxicity effects at up to the concentration of 0.75 μg/mL. Valspodar (0.25, 0.5 and 0.75 μg/mL) and DOX-L are added to the DOX resistant cells, and cell kill efficacy of MDR cell type increases significantly when valspodar is administered alongside DOX-L. Valspodar (0.5 and 0.75 μg/mL), in combination with all concentrations of DOX, are most toxic and kill more than 70% of the resistant cells. Pretreatment with PSC833 decreases the IC 50 value of NSC 279836 in MDA-MB-435mdr cells to 0.4±0.02 μM in MDR cells and almost completely reverses the resistance of MDR cells to NSC 279836.

valspodar (10 mg/kg, o.p.) exhibits minimal blood-cell partitioning as reflected in its low mean blood-to-plasma ratio of approximately 0.52. Valspodar displays properties of slow clearance and a large volume of distribution. Valspodar shows properties of low hepatic extraction and wide distribution, similar to that of its structural analogue CsA. Preadministration of PSC833 to mice increases NSC 279836 fluorescent intensity in MDR tumor to 94% of that in the wild-type tumors.

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产品供应商
Valspodar
询价
上海阿拉丁生化科技股份有限公司
2023-10-02

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