CAS号：1146963-51-0
|
英文名称：N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide
分子式
C18H17F3N2O2
分子量
350
EINECS号
1592732-453-0
MDL
MFCD25976644
Smiles
InChIKey
2,2,2-三氟乙酸 1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼化学百科
基本信息
| 中文名称 | J-147 |
| 英文名称 | J 147 |
| CAS号 | 1146963-51-0 |
| 分子式 | C18H17F3N2O2 |
| 分子量 | 350.33 |
| EINECS号 | 1592732-453-0 |
| InChI | InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3 |
| SMILES | C(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F |
物化性质
| 沸点 | 412.8±55.0 °C(Predicted) |
| 密度 | 1.18±0.1 g/cm3(Predicted) |
| 溶解度 | DMSO:68.0(最大浓度 mg/mL);194.1(最大浓度 mM) |
| 形态 | 粉末 |
| 酸度系数(pKa) | 0.80±0.50(Predicted) |
| 颜色 | 米白色至粉红色 |
安全信息
生产及用途
J-147 是一种特别有效的，具有口服活性的神经保护剂，可增强认知能力。J-147 可透过血脑屏障 (BBB)。J-147 抑制单胺氧化酶 B (MAO B) 和多巴胺转运体 (dopamine transporter)，EC50 分别为 1.88 μM 和 0.649 μM。J-147 有潜力用于阿尔茨海默氏症 (AD) 的研究。
MAO B; Dopamine transporter
J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC 50 value range of 0.06-0.115 μM) .
J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.
The half life (t
1/2
) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).
| Animal Model: | 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls |
| Dosage: | 200 ppm |
| Administration: | The diet was prepared by the addition of 200ppm; 6 months |
| Result: | While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147. |
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