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CAS号:1123231-07-1
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英文名称:WAY-262611
分子式
C20H22N4
分子量
318
EINECS号
604-604-1
MDL
MFCD20527803
Smiles
InChIKey
乙二醇化学百科
基本信息
物化性质
安全信息
生产及用途
WAY-262611是 Wnt/β- 联蛋白激动剂,可增加骨形成速率,在 TCF- 荧光素酶测定实验中的 EC50 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。 EC50: 0.63 μM (β-Catenin) WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β -catenin pathway and most likely through inhibition of Dkk-1.
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